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Research interests in my laboratory lie at the interface of chemistry and biology.
Our goal is to develop novel synthetic molecules that can modulate cellular signaling pathways with an emphasis on protein-protein interactions (PPIs). To this end, we take a multidisciplinary approach including synthetic organic chemistry, combinatorial chemistry, high-throughput screening, biochemistry, and molecular biology.

PPIs play pivotal roles in virtually every biological process and thus are emerging as promising therapeutic targets for various diseases including cancer. However, most such interactions cannot be readily disrupted by typical ‘drug-like’ small molecules, since protein interfaces are fairly large and shallow. To target PPIs, we focus on the development of different types of molecules, such as conformationally constrained macrocyclic molecules and protein surface mimetics. The resulting compounds will not only serve as highly useful research tools to elucidate the functions of target proteins, but also have a great potential as novel therapeutic candidates.

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