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  1. Lee, S. B.; Kwon, H. C.; Jee, E. K.; Kim, J. L.; Lee, K. J.; Kim, J. Y.; Ko, N. K.; Lee, E. S.*;Lim, H. S.* "Synthesis and Structural Characterization of Macrocyclic α-ABpeptoids and Their DNA-Encoded Library" Org. Lett. 2024, 26, 1100.
  2. Kumar, S.; Park, J. H.; Kim, H.-S.; Seo, C. D.; Ajish, C.; Kim, E. Y.; Lim, H. S.*; Shin, S. Y.* "Cationic, Amphipathic Small Molecules Based on a Triazine-Piperazine-Triazine Scaffold as a New Class of Antimicrobial Agents" Eur. J. Med. Chem. 2022, 243, 114747.
  3. Wang, H. M.; Seo, C. D.; Lee, K. J.; Park, J. H.; Lim, H. S. "Evaluation of the Cell Permeability of Bicyclic Peptoids and Bicyclic Peptide-Peptoid Hybrids" Bioorg. Chem. 2022, 127, 105976.
  4. Lee, K. J.; Bang, G.; Kim, Y. W.; Shin, M. H.; Lim, H. S "Design and Synthesis of a DNA-Encoded Combinatorial Library of Bicyclic Peptoids" Bioorg. Med. Chem. 2021, 48, 116243.
  5. Choi, S. R.; Wang, H. M.; Shin, M. H.; Lim, H. S. "Hydrophobic Tagging-Mediated Degradation of Transcription Coactivator SRC-1" Int. J. Mol. Sci. 2021, 22, 6407.
  6. Kim, H.-S.; Lee, Y.; Shin, M. H.; Lim, H. S. "Cell-Penetrating, Amphipathic Cyclic Peptoids as Molecular Transporters for Cargo Delivery" Chem. Commun. 2021, 57, 6800-6803.
  7. Hyun, S.; Park, N.; Nam, S. H.; Cheon, D. H.; Lee, Y.*; Lim, H. S.*; Yu, J.* "One-Bead-One-Compound Screening Approach to the Identification of Cyclic Peptoid Inhibitors of Cyclophilin D as Neuroprotective Agents from Mitochondrial Dysfunction." Chem. Commun. 2021, 57, 2388-2391.
  8. Park, J. H.; Wang, H. M.; Shin, M. H.; Lim, H. S. "Synthesis of a DNA-Encoded Library of Pyrrolo[2,3-d]pyrimidines." Bull. Korean Chem. Soc. 2021, 42, 691-698.
  9. Lee, Y.; Heo, J.; Jeong, H.; Hong, K. T.; Kwon, D. H.; Shin, M. H.; Oh, M.; Sable, G. A.; Ahn, G.; Lee, J. S.; Lim, H. S. "Targeted Degradation of Transcription Co-activator SRC-1 through the N-Degron Pathway." Angew. Chem. Int. Ed. 2020, 59, 17548-17555.
  10. Shin, M. H.; Lee, K. J.; Lim, H. S. "A DNA-Encoded Combinatorial Library of Macrocyclic Peptoids." Bioconjugate Chem. 2019, 30, 2931-2938.
  11. Lee, Y.; Im, H.; Das, S.; Oh, M.; Lee, J. H.; Ham, S.; Lim, H. S. "Bridged α-helix mimetic small molecules." Chem. Commun. 2019, 55, 13311-13314.
  12. Lee, Y.; Chung, B.; Ko, D. S.; Lim, H. S. "A solid-phase method for synthesis of dimeric and trimeric ligands: Identification of potent bivalent ligands of 14-3-3σ." Bioorganic Chemistry. 2019, 103141.
  13. Lee, K. J.; Sable, G. A.; Shin, M. K.; Lim, H. S. "Oligomers of α-ABpeptoid/β3-peptide hybrid." Biopolymers. 2019, 110:e23289.
  14. Sable, G.; Lee, K. J.; Lim, H. S. "Solid-Phase Synthesis and Circular Dichroism Study of b-ABpeptoids." Molecules. 2019, 24, 178-190.
  15. Sable, G.; Lee, K. J.; Shin, M. K.; Lim, H. S. "Submonomer Strategy toward Divergent Solid-Phase Synthesis of a-ABpeptoids." Org. Lett. 2018, 20, 2526-2529.
  16. Castaneda, M.; Chen, L.; Pradhan, L.; Li, S.; Zein, R.; Lee, Y.; Lim, H. S.; Nam, H. J.; Lee, J. "A Forkhead Box Protein C2 inhibitor: Targeting Epithelial-mesenchymal Transition and Cancer Metastasis." Chembiochem. 2018, 19, 1359-1364.
  17. Shin, M. K.; Hyun, Y. J.; Lee, J. H.; Lim, H. S. “Comparison of cell permeability of cyclic peptoids and linear peptoids.” ACS Combi. Sci. 2018, 20, 237-242.
  18. Park, Y.; Ryu, Y.; Wang, T.; Jung, Y.; Kim, S.; Hwang, S.; Park, J.; Bae, D.; Kim, J.; Moon, H.; Lim, H. S.; Kim, S. Y.; Chung, E.; Kim, K. H.; Kim, S.; Myung, S. J. “Colorectal cancer diagnosis using enzyme- sensitive ratiometric fluorescence dye and antibody- quantum dot conjugates for multiplexed detection.” Adv. Funct. Mater. 2018, 28, 1703450.
  19. Lee, Y.; Yoon, H.; Hwang, S. M.; Shin, M. K.; Lee, J. H.; Oh, M.; Im, S. H.; Song, J.; Lim, H. S.; “Targeted Inhibition of the NCOA1/STAT6 Protein-Protein Interaction” J. Am. Chem. Soc. 2017, 139, 16056-16059.
  20. Im, J.; Das, S.; Jeong, D.; Kim, C. J.; Lim, H. S.; Kim, K. H.; Chung, S. K.; “Intracellular and transdermal protein delivery mediated by non-covalent interactions with a synthetic guanidine-rich molecular carrier” Int. J. Pharm. 2017, 528, 646-654.
  21. Shin, M. H.; Lim, H. S. “Screening methods for identifying pharmacological chaperones” Mol. BioSyst. 2017, 13, 638-647.
  22. Lee, K. J.; Lee, W. S.; Yun, H.; Hyun, Y. J.; Seo, C. D.; Lee, C. W.; Lim, H. S. “Oligomers of N-substituted β2-homoalanines: peptoids with backbone chirality” Org. Lett. 2016, 18, 3678-3681.
  23. Lee, Y.; Lim, H. S. “Skp2 inhibitors: Novel anticancer strategies” Curr. Med. Chem. 2016, 23, 2363-2379.
  24. Oh, M.; Lee, J. H.; Moon, H.; Hyun, Y. J.; Lim, H. S. “A chemical inhibitor of the Skp2/p300 protein-protein interaction that promotes p53-mediated apoptosis.” Angew. Chem. Int. Ed. 2016, 55, 602-606.

    25. • Recommended in Faculty of 1000 Biology (http://f1000.com/prime/725957442).

  25. Lee, J. H.; Oh, M.; Kim, H. S.; Lee, H. S.; Im, W.; Lim, H. S. “Converting one-face α-helix mimetics into amphiphilic α-helix mimetics as potent inhibitors of protein-protein interactions.” ACS Combi. Sci. 2016, 18, 36-42.
  26. Moon, H.; Lim, H. S. “Synthesis and screening of small-molecule α-helix mimetic libraries targeting protein-protein interactions .” Curr. Opin. Chem. Biol. 2015, 24, 38-47.
  27. Moon, H.; Lee, W. S.; Oh, M.; Lee, H.; Lee, J. H.; Im, W.; Lim, H. S. "Design, solid-phase synthesis, and evaluation of a phenyl-piperazine-triazine scaffold as α-helix mimetics." ACS Combi. Sci. 2014, 16, 695-701.
  28. Lee, K. J.; Lim, H. S. "Facile method to sequence cyclic peptides/peptoids via one-pot ring-opening/cleavage reaction." Org. Lett. 2014, 16, 5710-5713.
  29. Lim, H. S. "Peptoid library and its application." Polymer Science and Technology, 2014, 25, 302-306 (in Korean).
  30. Oh, M.; Lee, J. H.; Wang, W.; Lee, H. S.; Burlak, C.; Im, W.; Hoang, Q. Q.; Lim, H. S. "Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson's disease-associated α-synuclein." Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 11007-11012.

    • Highlighted in Nat. Chem. Biol. 2014, 10, 795.
    • Highlighted in Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 12274.
    • Featured in Nature SciBX (doi:10.1038/scibx.2014.934).
  31. Adler, J. J.; Heller, B. L.; Bringman, L. R.; Rananhan, W. P.; Cocklin, R. R.; Goebl, M. G.; Oh, M.; Lim, H. S.; Ingham, R. J.; Wells, C. D. “Amot130 adapts Atrophin-1 Interacting Protein 4 to inhibit Yes-associated Protein signaling and cell growth.” J. Biol. Chem. 2013, 288, 15181-15193.
  32. Lee, H. S.; Jo, S.; Lim, H. S.; Im, W. “Application of binding free energy calculations to prediction of binding modes and affinities of MDM2 and MDMX inhibitors.” J. Chem. Inf. Model 2012, 52, 1821-1832.
  33.  Lee, J. H. and Lim, H. S. “Solid-phase synthesis of tetra-substituted pyrrolo[2,3-d]pyrimidines.” Org. Biomol. Chem. 2012, 10, 4229-4235.
  34.  Nelson-Mendez, A.; Aleksanian, S.; Oh, M.; Lim, H. S.; Oh, J. K. “Reductively-degradable polyester-based block copolymers prepared by facile polycondensation and ATRP: synthesis, degradation, and aqueous micellization.” Soft Matter. 2011, 7, 7441-7452.
  35.  Lee, J. H.; Kim, H. S.; Lim, H. S. “Design and facile solid-phase synthesis of conformationally constrained bicyclic peptoids.” Org. Lett. 2011, 13, 5012-5015.
  36.  Lee, J. H.; Zhang, Q.; Jo, S.; Chai, S. C.; Oh, M.; Im, W.; Lu, H.; Lim, H. S. “Novel pyrrolopyrimidine-based α-helix mimetics: cell permeable inhibitors of protein-protein interactions.” J. Am. Chem. Soc. 2011, 133, 676-679.
  37.  Lee, J. H.; Meyer, A. M.; Lim, H. S. “A simple strategy for the construction of combinatorial cyclic peptoid libraries.” Chem. Commun. 2010, 46, 8615-8617.
  38.  Lee, J.; Udugamasooriya, G.; Lim, H. S.; Kodadek, T. “Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates.” Nature Chem. Biol. 2010, 6, 258-260.
  39.  Kim, Y. C.; Wu, S. Y.; Lim, H. S.; Chiang, C. M.; Kodadek, T. “Non-proteolytic regulation of p53-mediated transcription through destabilization of the activator-promoter complex by the proteasomal ATPases.” J. Biol. Chem. 2009, 285, 34522-34530.
  40.  Lim, H. S.; Reddy, M. M.; Xiao, X.; Wilson, J.; Wilson, R.; Connell, S.; Kodadek, T. “Rapid identification of improved protein ligands using peptoid microarrays.” Bioorg. Med. Chem. Lett. 2009, 19, 3866-3869.
  41.  Lim, H. S.; Archer, T. C.; Kim, Y. C.; Hutchens, T.; Kodadek, T. “Rapid identification of the pharmacophore in a large peptoid inhibitor of the proteasome regulatory particle.” Chem. Commun. 2008, 1064-1066.
  42.  Lim, H. S.; Cai, D.; Archer, T. C.; Kodadek, T. “Periodate-triggered cross-linking reveals Sug2/Rpt4 as the molecular target of a peptoid inhibitor of the 19S proteasome regulatory particle.” J. Am. Chem. Soc. 2007, 129, 12936-12937.
  43.  Lim, H. S.; Archer, T. C.; Kodadek, T. “Identification of a peptoid inhibitor of the proteasome regulatory particle.” J. Am. Chem. Soc. 2007, 129, 7750-7751.
  44.  Xiao, X.; Yu, P.; Lim, H. S.; Sikder, D.; Kodadek, T. “Design and synthesis of a cell permeable synthetic transcription factor mimic.” J. Comb. Chem. 2007, 9, 592-600.
  45.  Xiao, X.; Yu, P.; Lim, H. S.; Sikder, D.; Kodadek, T. “A cell permeable synthetic transcription factor mimic.” Angew. Chem. Int. Ed. 2007, 46, 2865-2868.
  46.  Kanbe, Y.; Kim, M. H.; Nishimoto, M.; Ohtake, Y.; Yoneya, T.; Ohizumi, I.; Tsunenari, T.; Taniguchi, K.; Kaiho, S.; Nabuchi, Y.; Araya, H.; Kawata, S.; Morikawa, K.; Cho, J. C.; Kwon, H. A.; Lim, H. S.; Kim, H. Y. “Newly discovered orally active pure antiestrogens.” Bioorg. Med. Chem. Lett. 2006, 16, 4959-4964.
  47.  Kanbe, Y.; Kim, M. H.; Nishimoto, M.; Ohtake, Y.; Tsunenari, T.; Taniguchi, K.; Ohizumi, I.; Kaiho, S.; Nabuchi, Y.; Kawata, S.; Morikawa, K.; Cho, J. C.; Kwon, H. A.; Lim, H. S.; Kim, H. Y. “Discovery of thiochroman derivatives bearing a carboxy-containing side chain as orally active pure antiestrogens.” Bioorg. Med. Chem. Lett. 2006, 16, 4090-4094.
  48.  Kanbe, Y.; Kim, M. H.; Nishimoto, M.; Ohtake, Y.; Kato, N.; Tsunenari, T.; Taniguchi, K.; Ohizumi, I.; Kaiho, S.; Morikawa, K.; Cho, J. C.; Lim, H. S.; Kim, H. Y. “Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure-activity relationship.” Bioorg. Med. Chem. 2006, 14, 4803-4819.
  49.  Lim, H. S.; Park, J. J.; Ko, K.; Lee, M. H.; Chung, S. K. “Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors.” Bioorg. Med. Chem. Lett. 2004, 14, 2499-2503.
  50.  Lee, J. M.; Lim, H. S.; Seo, K. C.; Chung, S. K. “A practical diastereoselective synthesis of β-amino-α-hydroxy carboxylates.” Tetrahedron: Asymmetry 2003, 14, 3639-3641.
  51.  Lim, H. S.; Oh, Y. S.; Suh, P. G.; Chung, S. K. “Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors.” Bioorg. Med. Chem. Lett. 2003, 13, 237-240.
  52.  Lee, J. M.; Lim, H. S.; Chung, S. K. “A short and efficient stereoselective synthesis of all four diastereomers of sphingosine.” Tetrahedron: Asymmetry 2002, 13, 343-347.
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